Transient thrombopenia after intravenous injection of certain fatty acids

Transient thrombopenia after intravenous injection of certain fatty acids.

Intravenous injections of various fatty acids in rabbits caused marked thrombopenia lasting 1-2 hr. The most active saturated fatty acids were myristic acid (14:O) and lauric acid (12: 0). Activity decreased with increasing and decreasing chain length, but behenic acid (22 : 0) had, on a molar basis, activity similar to that of lauric acid. Of the unsaturated fatty acids, oleic acid (18: 1) was...

Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs

Six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride (50 mg/kg) to evaluate the pharmacokinetic parameters of the drug. Blood samples were collected before and at various time intervals after the administration of the drug. Serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. Non...

Tissue distribution of C-14 after the intravenous injection of labeled free fatty acids and chylomicrons in nephrotic rats.

Adsorption of free fatty acids on cells of certain microorganisms.

Information on the inhibitory effect of free fa t ty acids was sought by growing lactic streptococci in the presence of labeled fa t ty acids and collecting the cells on membrane filters. The distribution of the radioactivity indicated adsorption by the bacteria. As the number of cells in the growth medium increased, accumulation of radioactivity with the cells on the filter increased. The cell...

Studies on the Oxidation of Certain Fatty Acids.

In both plant and animal bodies, under certain conditions, sugars are changed to fats; and in the plant, if not in the animal, these fats are converted back to sugars for use when a certain other set of conditions is provided. These are well known facts of physiology. It is pretty well established that the point of departure is the fatty acid; that is, the fatty acid is formed before the neutra...